Tuning surface properties via geometrical structures is common in nature for generating some unique functions effectively.Spiders develop their web with periodic knots for collecting water; micro/nano structures on lotus leave are responsible for their superhydrophobicity; water-walking insects use retractable structures to pass from the water surface to land.The first part of this talk is on our work of developing a series of functional surfaces with tunable surface properties.Inspired by spider web with periodic knots and joints,we have fabricated spindle-like knot microfibers with microfluidic technique.These engineered-microfibers have a super capability of water collection: the maximum volume of water droplet collected by a knot is almost 300 times that of the knot.With the microfluidic technique,we have also developed honeycomb-like porous polymer films.The surface wettability can then be precisely manipulated by tuning surface morphology of polymer films like sizes and shapes of pores.Inspired by retractable structures used by meniscus-climbing insects,we have incorporated mobile wettable micropillars with a superhydrophobic background for in-situ switching surface adhesion to water.The micropillar-regulated surface resembles a mechanical hand which can capture,manipulate and deposit tiny water droplets in a precise and lossless manner.Mechanical vibration is often used by many animals like dogs,cats and birds to manipulate droplets generation for dispersing water effectively.In the second part of this talk,we will summarize our work on applying mechanical vibration for precise controlling of droplets generation in microfluidic co-flow systems.We characterize the droplet generation quantitatively by predicting flow-rate fluctuations.We show the correlation between the generation-frequency and uniformity of droplets and the frequency and amplitude of vibration,the synchronized droplet generation,and the ability of vibration in promoting dripping,suppressing jetting and shifting of jetting into dripping.These yield a better understanding of mechanism underlining the vibration-driving generation of droplets widely used by animals and benefit the engineering application of vibration-enhanced droplet generation in many fields including biochemistry,biomedical engineering,food industry,pharmaceuticals,and material sciences.