Porous tantalum produced via carbon vapor deposition/infiltration of commercially pure tantalum onto vitreous carbon scaffold is currently available for use in orthopedic applications.However, the relatively high cost of manufacture and an inability to produce modular implant has limited its widespread acceptance.In this study, chemical vapor deposition was used to coat tantalum on Ti6Al4V scaffolds with fully opened pore architectures and tailored mechanical properties.The porous Ti6Al4V scaffolds with and without tantalum coating were characterized.Mesenchymal stem cells were seeded on tantalum coated scaffolds to investigate the in vitro biocompatibility.The results showed excellent cellular adherence and growth on porous tantalum coated scaffolds compared to uncoated scaffolds, indicating that tantalum coated porous Ti6Al4V scaffolds could be an alternative to traditional orthopedic implants.