Discovery of novel N2,N4-disubstituted pyrimidine-2,4-diamines as potent CDK9 and CDK2 inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:yuhong8109
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  Cyclin-dependent kinases(CDKs)are pivotal kinases in eukaryocyte.As an important member of the CDK family,CDK9 plays a key role in the regulation of cell cycle as well as transcription and is regarded as a potential drug target in oncology,virology,cardiology and inflammation.
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