Metformin inhibits osteoclastogenesis in vitro and in vivo

来源 :2010广东省医学会骨科年会暨岭南骨科学术大会 | 被引量 : 0次 | 上传用户:kalok
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  studies have reported mefformin, an insulin-sensitizer drug commonly used for type 2 diabetes, could enhance differentiation and mineralization of osteoblasts in cell culture.However, its roles in osteoclastogenesis are not konwn.In this study we examined the effects of metformin on differentiation and function of osteoclasts and the involvement of mammalian target of rapamycin (mTOR) signaling, one of its targets in this process.
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