Deubiquitinase OTUD3 Regulates PTEN Stability and Suppresses Tumorigenesis

来源 :北京细胞生物学会2015年学术大会 | 被引量 : 0次 | 上传用户：echo_seaman

【摘要】

：

PTEN is one of the most frequently mutated tumor suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis.Although several ubiquit

【作者】

：

张令强

【机构】

：

军事医学科学院放射与辐射医学研究所

【出处】

：

北京细胞生物学会2015年学术大会

【发表日期】

：

2015年10期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

PTEN is one of the most frequently mutated tumor suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis.Although several ubiquitin ligases for PTEN have been identified, the deubiquitinase for de-polyubiquitination and stabilization of PTEN is less defined.

其他文献

A tetratricopeptide repeat domain-containing protein SSR1 is involved in root development and auxin

　　Auxin polar transport mediated by a group of Pin-formed (PIN) transporters plays important roles in plant root development.However, the mechanism underlying

会议

SSR1root developmentauxin transportPIN proteinmitochondria

Epithelial Cellular Function in Male Reproduction Role of Basal Cells in the Intercellular Networks

　　Epithelial cells form a barrier to separate the body from either the outside world or the milieu of organs.Proper intercellular communication is essential t

会议

epithelial functionbasal cellsintercellular communicationpumps and transporte

Integrin endocytosis on elastic substrates mediates mechanosensing

　　Tissue mechanics provides an appropriate niche for cell growth and functions.Integrin proteins play a pivotal role in mechanosensing associated with both ex

会议

matrix elasticityintegrinendocytosismechanosensing

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammali

　　Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and play an important role in diverse physiologic processes, including mitotic di

会议

mitotic spindle assemblydeubiquitinating enzymeBRISCNuMAK63-linked ubiquitin

Low EGFR_1 activatory human adjacent non-lung adenocarcinoma tissues neuroendocrine differentiation

Low epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b)oncogene homolog, avian) (EGFR_1) feedback-interactive knowledge network was select

会议

EGFR_1 feedback-interactive networkEGFR_1 activated-upstream networkEGFR_1 act

Ethanol Induced Egress of Intracellular Eimeria tenella Sporozoites Results in Slight Host Cells Dam

　　Eimeria spp.is a genus of apicomplexan parasites which can infect poultry and livestock and causes coccidiosis.The estimate of annual economic losses due to

会议

Eimerian parasitesEgressHost Cells Damage

High EGFR_1 repressive lung adenocarcinoma inflammatory or humoral immune response mechanism

High epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR_1) feedback-inhibitive knowledge network was selec

会议

EGFR_1 feedback-inhibitive networkEGFR_1 inhibited-upstream networkEGFR_1 inhi

Embryonic Attenuated Wntβ-catenin signal defines a niche that instructs stem cell emergence

　　Adult stem cells maintain tissue homeostasis and regeneration through-out the lifetime of an animal.However, it remains unknown how stem cell fate is establ

会议

hair follicle stem cellattenuated Wnt/β-cateninstem cell specification

Post-transcriptional regulation of keratinocyte progenitor cell expansion, differentiation and hair

　　Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest.The transitions from anagen (growth), to catagen (regression

会议

miR-22microRNAhair cyclingkeratinocyte differentiation

高原低氧、冷复合因素对大鼠血管内皮细胞的损伤作用及其防治研究

　　目的：低氧、冷是高原环境中影响人类健康的主要因素；血管内皮是易受到以上因素损伤的部位，内皮细胞的功能紊乱能够直接影响高原特发性疾病的发生进展；而逆转内皮细胞的功能紊

会议

低氧冷血管内皮细胞损伤防治

Deubiquitinase OTUD3 Regulates PTEN Stability and Suppresses Tumorigenesis

与本文相关的学术论文