Recently,CMYAS was suggested as a susceptibility gene for schizophrenia based on twoindependent studies utilizing differentethnic samples.We designed a case-controlstudy to examinewhether 21 SNPs containedwithin CMYAS were associated with the disorder in a western HanChinese sample comprised of 488 schizophrenia patients and 516 healthy control subjects.Theallele distribution of SNPs rs7714250,rs16877135 and rs13158477 showed significant associationwith schizophrenia(P=0.008,P=0.04,and P=0.009,respectively);the genotype distribution ofSNPs rs7714250 and rs13158477 also showed significant association with thedisorder(P=0.00004,and P=0.038,respectively).Analysis of haplotypes comprised of two haploblocks(rs16877133-rs16877135-rsI3158477 and rs28362541-rs3828611-rs12514461)showed significantassociation with schizophrenia(global P=4.91×10-7),and a significant difference was found for thecommon haplotype CTGTCGG(P=0.0033).Replicationof the association of CMYAS withschizophrenia across various studies suggest that it is very likely a potential commonschizophrenia-related gene worldwide.Functional studies correlating CMYAS with DTNBPI andPKA warrant further investigation of the molecular basis of this gene in relationship to the signaltransduction pathways)underlying the pathogenesis of schizophrenia.