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Objective To prospectively investigate the safety and efficacy of neoadjuvant radiotherapy with concurrent weekly oxaliplatin plus TS-1(nSOXRT)or TS-1 alone(nSRT)followed by D2 resection for locally advanced gastric cancer Methods The patients with stage ⅡB-ⅢC gastric cancer who received chemoradiotherapy(CRT)and surgery in Peking University Cancer Hospital from March 2009 to October 2014 were enrolled.