【摘 要】
：
Superparamagnetic iron oxides possess specific magnetic properties in the presence of an external magnetic field,which make them an attractive platform as contrast agents for magnetic resonance imagin
【机 构】
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CCS,ACS,CRS Taiwan
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Superparamagnetic iron oxides possess specific magnetic properties in the presence of an external magnetic field,which make them an attractive platform as contrast agents for magnetic resonance imaging (MRI) and as carriers for drug delivery.In this study,we investigate the drug delivery and the MRI properties of folate-mediated water soluble iron oxide incorporated into micelles.Pluronic(R) F 127 (PF 127),which can be self-assembled into micelles upon increasing concentration or raising temperatures,is used to decorate water-soluble polyacrylic acid-bound iron oxides (PAAIO) via a chemical reaction.Next,the hydrophobic dye Nile red is encapsulated into the hydrophobic poly(propylene oxide) compartment of PF127 as a model drug and as a fluorescent agent.Upon encapsulation,PAAIO retains its superparamagnetic characteristics,and thus can be used for MR imaging.A tumor-specific targeting ligand,folic acid (FA),is conjugated onto PF127-PAAIO to produce a multifunctional superparamagnetic iron oxide,FA-PF127-PAAIO.FA-PF127-PAAIO can be simultaneously applied as a diagnostic and therapeutic agent that specifically targets cancer cells that overexpress folate receptors in their cell membranes.
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