【摘 要】
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It is widely accepted that cell induced traction forces at the cell-matrix interface play essential roles in cell signaling,cell migration and tissue morphogenesis.Our previous study has constructed t
【机 构】
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Biomechanics and Biomaterials Laboratory,Department of Applied Mechanics,School of Aerospace Enginee
【出 处】
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第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议
论文部分内容阅读
It is widely accepted that cell induced traction forces at the cell-matrix interface play essential roles in cell signaling,cell migration and tissue morphogenesis.Our previous study has constructed the model of focal ad hesions to reveal the mechanism by which the traction forces regulate the growth of focal adhesions,but the distribution of the traction forces and how to be regulated also remain unclear.Experiments indicated that the traction forces increase linearly with the stiffness of substrate when the substrate is relatively soft,but then level off to a plateau value on sufficiently stiff substrate.
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