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Background:BloodhasbeenusedasasubstitutefortumortissueindetectingEGFRmutations.However,notallresultsindicatea consistencyofEGFRmutationstatusbetweenthebloodandtissues.Weconductedthissystematicreviewtoassesswhether bloodcanbeusedasareliablesourcefordetectingEGFRmutations.