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5. Trigeminal star-like platinum complexes target human telomere G-quadruplex:accelerating telomere sho

Trigeminal star-like platinum complexes target human telomere G-quadruplex:accelerating telomere sho

来源 :第九届全国无机化学学术会议 | 被引量 : 0次 | 上传用户：ieuieuieu

【摘 要】

：

The formation and stabilization of human telomeric G-quadruplex(hTel G4)structures can accelerate telomere shortening and/or induce telomere DNA damage,accordingly resulting in cancer cell senescence

【作 者】

：

Qian Cao Xiaohui Zheng Zongwan Mao 

【机 构】

：

Department of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou,510275

【出 处】

：

第九届全国无机化学学术会议

【发表日期】

：

2015年7期

【关键词】

：

G-quadruplex stabilizer telomere DNA damage telomerase activity anti-cancer effe 

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　　The formation and stabilization of human telomeric G-quadruplex(hTel G4)structures can accelerate telomere shortening and/or induce telomere DNA damage,accordingly resulting in cancer cell senescence and apoptosis.

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