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Scarring is a significant symptomatic clinical problem and is pathologically characterized by the excessive transformation of fibroblasts to myofibroblasts and deposition of extracellular matrix (ECM) components.IL-10 has been identified as a candidate scar-improvement therapy based on preclinical studies.However,the molecular mechanisms of IL-10 involved in scar formation have not been fully elucidated.In this study,cultured human dermal fibroblasts were treated with TGF-β1 and IL-10.The mRNA and protein expression levels of type Ⅰ collagen (Co11),type Ⅲ collagen (Co13),alpha smooth muscle actin (α-SMA) and matrix metalloproteinase-1 (MMP1) were assessed by quantitative real-time PCR and western blot.