【摘 要】
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Selectively copper-catalyzed aerobic oxidation of alcohol employing O2 (or air) as the terminal oxidant is regarded as a significant chemical transformation in organic synthesis.1 Although many oxidat
【机 构】
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College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014
【出 处】
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第十八届全国金属有机化学学术讨论会
论文部分内容阅读
Selectively copper-catalyzed aerobic oxidation of alcohol employing O2 (or air) as the terminal oxidant is regarded as a significant chemical transformation in organic synthesis.1 Although many oxidation methods exhibit efficient catalytic activity for benzylic alcohol, the reported ligands are confined to N,N-bidentate ligands and organic solvents are required for these catalytic systems.
其他文献
Heterocycle feature prominently in pharmaceuticals, agrochemicals and organic intermediates has provided a driving force for chemists to develop increasingly efficient methods toward their synthesis.1
钳形钯化合物已被证明是催化Suzuki、Heck、Sonogashira、Aldol、Michael加成等多种类型反应的有效催化剂[1].特别是近年来的研究发现,一些手性的钳形钯化合物在不对称催化反应中也能表现出高度的立体选择性,例如:使用含有手性苄基的双(膦烷)PCP钳形钯化合物作为催化剂,烯酮、硝基烯烃等缺电子烯烃的膦氢化反应均获得了优异的对映体选择性[2].
吡啶官能团化的手性膦烷是金属有机化学中非常重要的一类双齿N,P配体,被广泛地用于金属催化的不对称有机反应中[1].近年来,在金属或有机分子催化下,烯酮、硝基烯烃等缺电子烯烃与仲膦烷(R2PH)的不对称膦氢化反应取得了很大的进展,其中,以环钯[2],21和PCP钳形钯化合物[3]催化剂最为高效,利用该反应可以方便地制备多种类型的手性膦烷化合物.
光学活性的炔基叔醇是多种天然产物、药物和生物活性分子的结构单元,也是有机合成中非常有用的合成砌块,通过酮的不对称炔基化反应合成这类化合物是最直接、最有效的方法之一[1];另一方面,含三氟甲基的光学活性炔基叔醇也是一些药物分子的关键中间体、含三氟甲基的其它光学活性有机化合物在农药和材料等领域也有着重要的应用[2].
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C-C bond formation on inert C-H bond features good atom-and step-economy and hence has attracted much interest.Major achievements in this field focused on the activation of C(sp2)-H bond1 while the re
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