Numerous studies have demonstrated that intraoperative remifentanil infusions have been associated with postoperative opioid-induced hyperalgesia (OIH) and tolerance.Activation of delta-opioid recepto
Unilateral chronic constriction injury (uCCI) of rat sciatic nerve is a common neuropathic pain animal model.However, the extent to which uCCI actually mimics any particular clinical neuropathic pain
Perioperative stroke is one of the most detrimental complications of surgeries.It may cause cognitive dysfunction, disability and even death.Various studies have dedicated in the prevention or treatme
Remote ischemic preconditioning may confer the cytoprotection in critical organs.We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patien
背景 最近的研究表明丙泊酚和右美托嘧啶等全身麻醉药和镇静药作用于各自特异性分子靶点,但他们在神经网络层面是否也具有特异性作用却不得而知.有证据表明,脑皮质在麻醉或睡眠时可引起"top-down"抑制,但也有一些研究显示这些药物是通过皮层下机制发挥镇静作用,并且很可能与自然睡眠的神经网络路径一致.目的 本研究旨在揭示睡眠与麻醉机制在神经网络层面的相似性,并证实在意识消失过程中,脑内不同核团的变化差异
Early growth response (Egr)-1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R).1 Activation of extracellular signal-regulated protein
目的 由于手术病人自身心脑血管疾病、外科操作和麻醉等原因,围术期脑缺血损伤并不少见且后果极其严重.我们前期研究发现高压氧等非缺血预处理措施可诱导显著的脑保护效应.然而,在我们的大样本研究中发现一个重要问题,预处理措施并不能使所有动物或患者从中受益.为什么相同的预处理措施会产生不同的效应?由于动物/患者间显著的个体差异,每一接受预处理的个体需要接受不同程度的处理才能激活其内源性保护机制,诱导缺血耐受
Intestinal ischemia/reperfusion (Ⅱ/R) is associated with high morbidity and mortality, and recent increasing data have shown that hydrogen gas (H2) can neutralize free radicals and reduce oxidative st
麻醉和睡眠本质上不同,但在某些环节可能有相似之处.研究显示:脑内存在睡眠和觉醒两大调节系统,分别由众多的神经核团和递质(调质)组成,受内源性睡眠调节物质和生物节律的调控.觉醒系统包括:脑干网状结构、臂旁核谷氨酸能神经元、蓝斑核去甲肾上腺素能神经元、中缝背核5-羟色胺能神经元、中脑多巴胺能神经元、外背侧被盖核/脚桥被盖核/脑桥-中脑/基底前脑乙酰胆碱能神经元、下丘脑后部结节乳头核(tuberomam
Both type 1 and type 2 diabetes mellitus substantially increase the risk for cerebral ischemic reperfusion injury.In addition, cerebral ischemic reperfusion injury is one major cause of morbidity and