Corticosterone increases heme uptake via KLF4-mediated enhancement of HCP1 expression in the brain o

来源 :中国营养学会第十三届全国营养科学大会暨全球华人营养科学家大会 | 被引量 : 0次 | 上传用户:chzhao2005
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Objective Heme,a ferrous protoporphyrin IX that serves as the major source of iron in the body,plays a pivotal role in iron metabolism and myriad cellular processes,including electron transport,gas synthesis,gas sensing,signal transduction,microRNA processing,and maintenance of circadian clock.However,an excessive amount of free heme promotes lipid peroxidation and increase oxidative stress through generation of reactive oxygen species (ROS).
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