Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine formula consisting of six herbs, had been reported to possess neuroprotective effect.The present study aimed to investigate the effects of BSYZ on learning and memory abilities, oxidative stress and neuronal apoptosis in the hippocampus of scopolamine-induced mice, in order to reveal whether BSYZ is a potential therapeutic agent for Alzheimer's disease (AD).In our study, high performance liquid chromatography (HPLC) fingerprint was applied to provide a chemical profile of BSYZ.Extracts of BSYZ were orally administered to scopolamine-induced memory impairment mice for two weeks.