【摘 要】
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Interleukin-6 (IL-6) is a multifunctional cytokine involved in different physiologic and pathophysiologic processes and plays important roles in the etiology of cancer.The-174G[C polymorphism of the I
【出 处】
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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
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Interleukin-6 (IL-6) is a multifunctional cytokine involved in different physiologic and pathophysiologic processes and plays important roles in the etiology of cancer.The-174G[C polymorphism of the IL-6 gene influencesIL-6 transcription and has been implicated in cancer risk.However, published data have been conflicting.To derive a more precise estimation of the relationship, a meta-analysis of 29,377 cancer cases and 37,739 controls from 50 published cases—control studies was performed.Odds ratios (Ors)with 95% confidence intervals (Cis) were estimated to assess the association between-174G> C polymorphism and cancer risk.Overall meta-analysis indicated that noassociation was found between-174G>C genotypes and cancer risk.However, the positive association was found in bladder cancer (OR =4.33, 95% CI: 1.93-9.71 for CC vs.GC, OR =2.81,95% CI: 1.39-5.68 for CC vs.GG, and OR =2.19, 95% CI: 1.32-3.64 for CC vs.GG/GC), and among Asians (OR =2.08,95% CI: 1.07-4.06 for CC vs.GG, and OR =2.20, 95% CI:1.02-4.74 for CC vs.GG/GC) and Africans (OR =1.61, 95%CI: 1.07-2.42 for GC vs.GG).This meta-analysis showed the evidence that the-174G>C of the IL-6 gene was a lowpenetrance susceptibility gene for bladder cancer.Further larger, preferably prospective studies are needed to confirm this relationship.
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