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Objective Byco-cultureof hMSCsandHUVECsinhypoxia,simulateamicroenvironmentsimilartowhere transplantationofhMSCsfortreatmentofANFHandinvestigatetheeffectofhumanmesenchymalstemcells(hMSCs)onsurvival,apoptosis,migrationandangiogenesisofhumanumbilicalveinendothelialcells(HUVECs) underthehypoxicconditioninvitro.