The Origin of Substrate and Product Specificities of Protein Lysine Methyltransferase Suv4-20h2

来源 :第十三届全国量子化学会议 | 被引量 : 0次 | 上传用户：djing331

【摘要】

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【作者】

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Ping Qian Haobo Guo Liang Wang Hong Guo

【机构】

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Shandong Agricultural University,Chemistry and Material Science Faculty,Tai'an 271018,Shandong,Peop

【出处】

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第十三届全国量子化学会议

【发表日期】

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2017年10期

【关键词】

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Protein lysine methyltransferases (PKMTs) QM/MM Molecular dynamics Free energy S

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　　Protein lysine methyltransferases(PKMTs)catalyze the methylation of lysine residues on the tails of histone proteins.In contrast to many other PKMTs for which unmodified lysine is the methylation target,the enzymes in the Suv4-20 family are able to generate di-methylated product(H4K20me2)based exclusively on mono-methylated H4K20 substrate(H4K20me1).

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The Origin of Substrate and Product Specificities of Protein Lysine Methyltransferase Suv4-20h2

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