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Adrenomedullin 2(ADM2)is an endogenous bioactive peptide belonging to the calcitonin gene-related peptide(CGRP)family.Our previous studies showed overexpression of ADM2 in mice reduced obesity and insulin resistance by increasing thermogenesis in brown adipose tissue.However,the effects of ADM2 in another thermogenic adipocyte,beige adipocyte,remain to be understood.