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The use of genetic recombination technology to enhance the oncolytic properties of NDV has become a trend in anti-tumor study of NDV, Put some foreign gene which have both strong anti-tumor effect and large side effects to nomal tissue and NDV or Modified NDV restructuring of the foreign gene can be specifically brought to the tumor cells while reducing damage to normal tissues.NDV recombinant NDV can play better anti-tumor strengths and unique advantages of foreign genes to make the best of both synergistic anti-tumor effect.