【摘 要】
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Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive.To drive a more precise estimation, we performed a meta-analysis based on 1,06
【机 构】
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State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of N
【出 处】
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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
论文部分内容阅读
Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive.To drive a more precise estimation, we performed a meta-analysis based on 1,060 cases and 1,225 controls from 7 published casecontrol studies.PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship.Crude odds ratios (Ors) with 95%confidence intervals (Cis) were used to assess the strength of association in the additive model, dominant model,recessive model, and allele-frequency genetic model.In the overall analysis, the frequency of CYP1A1*2A genotype was significandy associated with susceptibility to idiopathic male infertility.Further stratified analysis by ethnicity showed notable association between the polymorphism and risk of idiopathic male infertility in Asians.In conclusion,these results support that the CYP1A1*2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians.
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