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  5. Interaction between Gold Nanoparticles and Alzheimer's Disease Related Aβ25-35 Peptide

Interaction between Gold Nanoparticles and Alzheimer's Disease Related Aβ25-35 Peptide

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：liongliong501
【摘 要】
：
The Aβ25-35 peptide is a peculiar peptide that differs from all the other commonly studied β-amyloid peptides because of its extremely rapid aggregation properties and its aggregates would be highly t
【作 者】
：
Jian Peng Liping Sun 
【机 构】
：
Department of Biomaterials,College of Materials,Research Center of Biomedical Engineering,Xiamen Uni
【出 处】
：
International Conference on Nanoscience & Technology,China 2
【发表日期】
：
2013年3期
【关键词】
：
gold nanoparticles Aβ25-35 peptide Alzheimer's disease monomer oligomer fib 
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　　The Aβ25-35 peptide is a peculiar peptide that differs from all the other commonly studied β-amyloid peptides because of its extremely rapid aggregation properties and its aggregates would be highly toxic and result in Alzheimers disease.Here, the interactions between gold nanoparticles (GNPs) and Aβ25-35 monomers, oligomers and fibrils under different molar ratio, temperature and pH are explored by ultraviolet-visible (UV-Vis) and circular dichromatism (CD) spectra,thioflavin T (ThT) fluorescence assay and transmission electron microscope (TEM).
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