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5. Forebrain-restricted knockout of rap1 genes facilitates the extinction of conditioned fear and enhan

Forebrain-restricted knockout of rap1 genes facilitates the extinction of conditioned fear and enhan

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：edison2920

【摘 要】

：

We have previously shown that double knockout(KO)of rap1 genes(rap1a and rap1b)in forebrain led to impairment of auditory fear conditioning.However,it remains unknown whether Rap1 is also required for

【作 者】

：

Chen Song Bing-Xing Pan 

【机 构】

：

Laboratory of Fear and Anxiety Disorder,Institute of Life Science,Nanchang University,Nanchang,Jiang

【出 处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

Rap1 fear extinction mPFC amygdala c-Fos 

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　　We have previously shown that double knockout(KO)of rap1 genes(rap1a and rap1b)in forebrain led to impairment of auditory fear conditioning.However,it remains unknown whether Rap1 is also required for the fear extinction,a new and “inhibitory” learning involving medial prefrontal cortex(mPFC).

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