【摘 要】
：
近年来快速发展起来的多功能纳米载运体系,不仅具有药物递送和肿瘤靶向的功能,而且还具有核磁共振及荧光成像能力,在肿瘤诊治等生物医药领域有着巨大应用潜力.发展高效便捷的多功能纳米载体制备方法,并借助核磁共振成像技术,提供可重复性在体、实时、无创、可视化分子信息,检测肿瘤的发展进程及药物释放信息,是一项挑战.本研究报道了基于便捷自组装策略,制备一体化多功能纳米载运体系的技术方法.所制备的多功能纳米载运体
【机 构】
：
大连工业大学食品学院,国家海洋食品工程技术研究中心,116034,大连 中国科学院大连化学物理研究
【出 处】
：
第七届全国低场核磁共振技术与应用研讨会
论文部分内容阅读
近年来快速发展起来的多功能纳米载运体系,不仅具有药物递送和肿瘤靶向的功能,而且还具有核磁共振及荧光成像能力,在肿瘤诊治等生物医药领域有着巨大应用潜力.发展高效便捷的多功能纳米载体制备方法,并借助核磁共振成像技术,提供可重复性在体、实时、无创、可视化分子信息,检测肿瘤的发展进程及药物释放信息,是一项挑战.本研究报道了基于便捷自组装策略,制备一体化多功能纳米载运体系的技术方法.所制备的多功能纳米载运体,不仅具有肿瘤靶向识别能力,而且具有光学成像,核磁共振成像以及肿瘤光热治疗能力.其微观结构为一种长约20.2 纳米,宽为2.72 纳米棒.纵向弛豫率为9.43 mM-1·s-1.荧光染料的光稳定性提高了约21％.在浓度0.5 mg·mL-1 的条件下,细胞的活率可以保持在80％以上.核磁共振活体成像结果表明,肿瘤靶向多功能纳米载体ICG-FA-PPD 表现出显著的时间依赖性肿瘤信号增强,注射后24 到72 小时,较非靶向对照组ICG-PPD,表现出较强的核磁信号增强,注射后48 小时信号提高了6.29 倍,48小时提高了13.3 倍.同样荧光信号在注射后48 小时提高了90％,48 小时提高了173％.并且表现出显著的肿瘤光热杀伤能力.
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