Objective: Castration-resistant prostate cancer (CRPC) remains a major clinical challenge.To date, the mechanisms responsible for histological evolution and subsequent acquired drug resistant clinical
Objective: The study aims at investigating the radiosensitivity induced by MLN4924, a specific Nedd8-activating enzyme inhibitor, and the underlying radiosensitizing mechanisms in prostate cancer cell
目的: Stathmin was known as a P53-regulated proteinand played an oncogenic role in a range of human malignancies.Paradoxically, most recent studies demonstrated that stathmin has a dual function as both