Objective: Small ubiquitin-like modifier 4 (SUMO4) is a post-translational modifier and closely related to inflammation process.It has been reported that SUMO4 gene polymorphism not only associated with type 1 diabetes, but also with type 2 diabetes in several Asian populations.This study aimed to detect the potential association of SUMO4 gene polymorphisms with susceptibility to type 2 diabetes by a case-control study in Chinese population and meta analyses.Methods: Participants included 100 patients with T2D and 500 controls.The 4 single nucleotide polymorphisms (SNPs) in SUMO4 gene were genotyped by polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with gene sequencing.The relationship of allelic and genotypic frequencies of the SUMO4 gene with the risk of T2DM was evaluated by the crude and adjusted odds ratios (ORs) with their 95%confidence intervals (CIs)from multivariate logistic regression models.Then we reviewed the association between rs237025and T2DM in Asian populations via a meta-analysis.Results: The G allele frequency of rs17506789 in T2DM 2patients was significantly higher than those of controls group (OR =1.836,P=0.02).The logistic regression analysis adjusted by gender and age showed significant association for rs17506789 GG+GA genotype.(OR =1.831, P =0.032).However, no association was observed for rs237025 in our sample.We identified five other studies for rs237025 (2562T2DM patients and 2509controls) in Asian.Meta-analysis indicated significant associations for the rs237025 G allele (OR =1.15, 95%CI =1.05-1.25, P =0.002).Subjects having haplotype AACwere more susceptible to T2DM in the Chinese population(OR=1.5, P=0.02).Conclusion:SNPsrs17506789 and rs237025 are associated with susceptibility to T2DM, and haplotype AAC also contributes to incidence of T2DM.