Phase 1/2 study of nivolumab with or without ipilimumab for treatment of recurrent SCLC:CA209-032 (N

来源 :第十八届全国临床肿瘤学大会暨2015年CSCO学术年会 | 被引量 : 0次 | 上传用户：zjtiankong1981

【摘要】

：

　　Objective: Patients (pts) with SCLC respond to initial platinum (PLT) based chemotherapy (CT), but rapidly progress.Combined blockade of programmed death-1

【作者】

：

ScottAntonia[1]JohannaBendell[2]MatthewTaylor[3]EmilianoCalvo[4]DirkJ(a)iger[5]FilippoDebraud[6]Patricka.Ott[7]M.catherinePietanza[8]LeoraHorn[9]Dungt.Le[10]Michaela.Morse[11]Joséa.López-martin[12]Pao

【机构】

：

Thoracic Oncology Department, H.Lee Moffitt Cancer Center & Research Institute

【出处】

：

第十八届全国临床肿瘤学大会暨2015年CSCO学术年会

【发表日期】

：

2015年期

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　　Objective: Patients (pts) with SCLC respond to initial platinum (PLT) based chemotherapy (CT), but rapidly progress.Combined blockade of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) immune checkpoint pathways has anti-tumor activity with a manageable safety profile.

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Phase 1/2 study of nivolumab with or without ipilimumab for treatment of recurrent SCLC:CA209-032 (N

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