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Osteoporosis represents a significant side-effect of glucocorticoid therapy, and alendronate is reported to prevent the glucocorticoid-induced osteoporosis.The functional imaging technique of 18F-fluoride positron emission tomography (PET) allows quantitative analysis of bone metabolism in specific skeletal regions.However, only a few studies have determined quantitatively bone turnover and metabolism in glucocorticoid-induced osteoporosis by radiological imaging techniques including PET.