【摘 要】
：
目的 研究不同时间慢性间歇低氧对外周血多形核白细胞凋亡的影响.方法 36只Wistar大鼠分为正常氧组(NIH组)和间歇低氧组(IH组),分别于暴露后4周、6周、8周麻醉后腹主动脉取血,分离外周血多形核白细胞(PMN),流式细胞仪进行凋亡检测.结果 IH组大鼠PMN凋亡率均低于NIH组,4周组NIH组vs IH组(23.64±8.42 vs15.72±7.95；p＜0.05)；6周组NIH组vs
【机 构】
：
天津医科大学总医院呼吸科 300052
【出 处】
：
The Third Internaitional Conference on Respiratory Diseases(
论文部分内容阅读
目的 研究不同时间慢性间歇低氧对外周血多形核白细胞凋亡的影响.方法 36只Wistar大鼠分为正常氧组(NIH组)和间歇低氧组(IH组),分别于暴露后4周、6周、8周麻醉后腹主动脉取血,分离外周血多形核白细胞(PMN),流式细胞仪进行凋亡检测.结果 IH组大鼠PMN凋亡率均低于NIH组,4周组NIH组vs IH组(23.64±8.42 vs15.72±7.95；p＜0.05)；6周组NIH组vs IH组(24.64±10.03 vs 15.90±11.80；p＜0.05)；8周NIH组vs IH(29.71±11.65 vs 20.54±6.42；p＜0.05),随着IH时间的延长,PMN凋亡率有上升趋势.
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