【摘 要】
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We recently discovered that mice repress fatty acid and triglyceride synthesis in the liver and mobilize fat stores from abdominal adipose tissue maintained on a diet deficient for an essential amino
【机 构】
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Institute for Nutritional Sciences,SIBS,CAS
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We recently discovered that mice repress fatty acid and triglyceride synthesis in the liver and mobilize fat stores from abdominal adipose tissue maintained on a diet deficient for an essential amino acid leucine.While exploring molecular mechanisms underlying, we found that CNS leucine plays an important role in regulating fat loss under leucine deprivation.Furthermore, leucine deprivation-decreased fat mass is controlled by unregulated corticotrophin-releasing hormone expression in the hypothalamus and activated sympathetic nervous system activity.Our observations thus provide novel and important insights concerning CNS leucine as a signaling moleuclar in the regulation of energy homeostasis.
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