【摘 要】
:
目的:评价脱脂菜籽粕来源的多肽在自发性高血压大鼠的降压和抗氧化作用.方法:对SHR大鼠进行一次性给药和长期给药灌喂多肽FL和VSV,测定SBP以及血清,肝脏和脑组织中的SOD、CAT的活性,及MDA、GSH水平.结果:FL和VSV在一次性和长期给药实验均显着降低SBP.讨论:水合分子对接研究揭示了VSV抑制ACE与ACE通过复杂的结合和互动机制,VSV表现出较强的抑制作用ACE比FL.FL和VSV
【机 构】
:
浙江大学食品科学与营养系,浙江杭州 310029
【出 处】
:
中国食品科学技术学会第十届年会暨第七届中美食品业高层论坛
论文部分内容阅读
目的:评价脱脂菜籽粕来源的多肽在自发性高血压大鼠的降压和抗氧化作用.方法:对SHR大鼠进行一次性给药和长期给药灌喂多肽FL和VSV,测定SBP以及血清,肝脏和脑组织中的SOD、CAT的活性,及MDA、GSH水平.结果:FL和VSV在一次性和长期给药实验均显着降低SBP.讨论:水合分子对接研究揭示了VSV抑制ACE与ACE通过复杂的结合和互动机制,VSV表现出较强的抑制作用ACE比FL.FL和VSV促进抗氧化酶SOD和CAT的活性,增加脑组织MDA水平,降低GSH水平降低了不同程度的高血压长期口服后.
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