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Hepatitis B virus (HBV) is a kind of hepatotropic DNA virus with unique structure, which is the main cause of acute and chronic hepatitis, liver cirrhosis and liver cancer.The imbalance of immune response to HBV is one of the important mechanisms of chronic hepatitis B infection.Western medicine treatment of hepatitis B is currently the core task of anti-virus, the goal is to completely clear the body of hepatitis B virus, but from the realization of this goal is still far away.Because of its serious adverse reactions, expensive, and easy to produce drug resistance, it is difficult in clinical wide application.Traditional Chinese medicine and natural medicine has the advantages of multi-link and multi-target effect, which has caused a wide range of domestic and foreign workers.Attention.This article will use hepatitis B virus as an example of traditional Chinese medicine and natural medicine analyzing the research resu1ts and prospects in the field of anti-virus.