【摘 要】
:
The genus Pholidota(Orchidaceae)belongs to the tribe Coelogyneae,and comprises ca.30 species with a distribution from tropical Asia to tropical Australia.Among them,ca.14 species occur in China[1].Pho
【机 构】
:
Hunan Province Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,Huna
【出 处】
:
第一届《药学学报》药学前沿论坛暨2015年中国药学会中药与天然药物专业委员会会议
论文部分内容阅读
The genus Pholidota(Orchidaceae)belongs to the tribe Coelogyneae,and comprises ca.30 species with a distribution from tropical Asia to tropical Australia.Among them,ca.14 species occur in China[1].Pholidota Cantonensis Rolfe.,named ‘Xi-Ye-Shi-Xian-Tao’ in Chinese,is a Chinese folk herbal medicine,with a long history of safe use for treating sore throat,tonsillitis,cough phlegm asthma,pneumonia,acute soft tissue trauma and arthritis[2,3].Previous phytochemical study on P.cantonensis showed the existence of stibenoids,cycloartane triterpenoid and phenylpropanoids[4,5].Based on the previous study the 80%ethanol extract of the whole plant P.cantonensis was separated by chromatography on silica gel,Sephadex LH-20,MCI gel and afford 22 compounds,the structures of compounds were elucidated on the basis of the chemical evidence and 1H-NMR,13C-NMR,2D-NMR and MS spectral.Four new constituents were isolated by the column chromatography over silica gel,MCI gel,RP-18 silica gel,Sephadex LH-20 and pre-HPLC from the EtOH extract of the air-dried whole plant of Pholidota cantonensis Rolfe.,together with 18 known compounds.The structures of the new compounds were established as 1-hydroxy-2,7-dimethoxy-9,10-dihydrophenanthrene-[4,5-bcd] furan(1),5-hydroxy-2,7-dimethoxy-9,10-dihydro-1,4-Phenanthrenedione(2),ent-labd-13(E)-ene-3α,8β,15-tri-3-O-β-D-glucopyranoside(3),5α,10β-ent-cleroda-3,13(E)-diene-15,18-diol-15-O-β-D-glucopyrannoside-18-O-β-Dglucopyrannoside(4)by chemical and spectroscopic methods,including 1D and 2D NMR.
其他文献
“清、透、养”三法,即清里热、透邪外出、养阴生津,是针对温病是由于外感四时温热邪气所引起的,以发热为主症,发病过程中始终存在着“热郁”这一病机特点而确立的治疗温病的基本法则,其运用贯穿于温病治疗的始终。
目的 研究制黄精水煎剂对环磷酰胺致骨髓抑制小鼠外周血及脏器指数的影响。方法 小鼠腹腔注射环磷酰胺,建立骨髓抑制模型,同时进行生理盐水灌胃和低、中、高剂量400、800、1200mg/kg 制黄精水煎剂灌胃,分别于造模的第7、10、14 天检测各组小鼠外周血RBC、Hb、Plt、WBC 的值及胸腺指数、脾脏指数。
两色金鸡菊(Coreopsis tinctoria Nutt.)为菊科(Compositae)金鸡菊属(Coreopsis)一年生草本植物,原产于美洲,后分布于世界各地[1],在我国主要分布于新疆南疆地区海拔3000 m 左右的昆仑山区,故又称“昆仑雪菊”.前期研究发现两色金鸡菊提取物在调节凝血功能方面有较好的作用,可有效的延长小鼠的出、凝血时间,但对于提取物化学成分的吸收及代谢研究未见报道,尤其
糖尿病是一种多病因引起、以高血糖为特征的内分泌代谢紊乱性疾病,α-葡萄糖苷酶抑制剂在预防和治疗Ⅱ型糖尿病的过程中起着关键作用.绵枣儿来源于风信子科植物绵枣儿Scilla scilloides(Lindl.)Druce的干燥鳞茎,始载于《救荒本草》,在民间具有食用和药用历史.前期实验表明绵枣儿乙醇提取物具有显著的糖苷酶抑制活性,本实验采用体外酶抑制活性结合超滤质谱法从中筛选潜在的α-葡萄糖苷酶抑制剂
在计算机辅助药物设计研究中,大分子蛋白质结构的柔性是高通量虚拟筛选所面临的重要问题。近年来,随着结构生物学的飞速发展,越来越多的蛋白晶体结构被解析报道,因此,基于多个蛋白结构的整体对接(ensemble docking)技术可有效的处理蛋白柔性问题。本研究针对自身免疫性疾病治疗领域的新型靶标——淋巴酪氨酸特异性磷酸酶(LYP)的多个晶体结构,发展了一个基于对接的虚拟筛选模型。方法学研究表明,与单一
Geniposide(genipin 1-O-glucose),which is one of the major bioactive constituents isolated from Fructus Gardeniae,possesses many biological activities[1].Here,an efficient strategy(Figure 1)was develop
AP2/ERF 转录因子家族是植物最大转录因子家族之一,调控药用植物活性成分的生物合成.丹参作为中药研究的理想模式植物,AP2/ERF对丹参酮和丹酚酸合成的调控作用未见报道.本研究基于丹参全基因组和转录组数据系统分析了AP2/ERF转录因子家族的序列特征、基因结构和基因表达谱.预测可能参与丹参酮和丹酚酸合成相关AP2/ERF转录因子.
With more and more advanced technologies and expenses were used in R&D,novel drug discovery is more difficult than ever.Correct drug combination is able to achieve good therapeutic effect because of s
研究和分析肝衰竭湿热证和肝衰竭寒湿证患者血清内源性小分子代谢物的差异,鉴定与中医证型相关的生物标志物。正常对照组25例,肝衰竭寒湿证组18 例,肝衰竭湿热证组22例。采用基于UPLC-Q-TOF/MS的代谢组学方法获得各组血清代谢轮廓图,应用正交偏最小二乘判别分析(OPLS-DA)分别比较肝衰竭寒湿证组和正常对照组、肝衰竭湿热证组和正常对照组,结合变量重要性分析(VIP,VIP > 1),鉴定引起
制备石杉碱甲(Hup-A)缓释固体自微乳并进行评价.采用球晶造粒技术对Hup-A 自微乳进行固化; 运用粒径分析仪与透射电镜测定固体自微乳粒径、zeta电位及微乳形态; 考察粉体学性质; 测定体外释放度.结果表明,Hup-A 固体自微乳的平均粒径及zeta电位为:(20.97 ± 0.68)nm和(-19.4 ± 0.52)Mv,TEM下呈大小均匀的圆球形; 固体自微乳为圆整球形,具有较好的流动性