miR-136通过靶向PPP2R2A调节TGF-β1对角质形成细胞增殖的抑制作用

来源 :首届全国组织修复与再生医学大会暨国际组织修复与再生医学学术研讨会 | 被引量 : 0次 | 上传用户：kinds1118

【摘要】

：

目的:角质形成细胞的增殖能力对于伤口愈合至关重要,而由成纤维细胞和角质形成细胞分泌的TGF-β1对角质形成细胞的增殖具有阻滞作用.越来越多的研究表明,microRNA参与调节角质形成细胞的增殖,而其中的分子机制仍有待阐明.本文旨在明确miR-136在TGF-β1诱导的角质形成细胞增殖阻滞中的作用,并探索其机制.方法:以HaCaT细胞系和人包皮皮片中分离的角质形成细胞为实验对象,建立TGF-β1诱导

【作者】

：

张殿宝王竞王暂张涛施萍王喜良赵峰刘晓玉林学文庞希宁

【机构】

：

中国医科大学,卫生部暨教育部医学细胞生物学重点实验室,干细胞与再生医学研究室,沈阳110122 中

【出处】

：

首届全国组织修复与再生医学大会暨国际组织修复与再生医学学术研讨会

【发表日期】

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2015年9期

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miR-136通过靶向PPP2R2A调节TGF-β1对角质形成细胞增殖的抑制作用

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