Inflammationis a protective biological response to body/tissue damages that involves immune cells,blood vessels and molecular mediators.In this work,we constructed the pathway network of inflammation,including 11 sub-pathways of inflammatory factors.Pathway-based network efficiency and network flux were adopted to evaluate drug efficacy.By using approved and experimentally validated anti-inflammatory drugs as training sets,a predictive model was built to screen potential anti-inflammatory drugs from approved drugs in DrugBank.This drug repositioning approach would bring a fast and cheap way to find new indications for approved drugs.Moreover,molecular phenomics profiles ofthe expression of inflammatory factors willprovide new insight into drug mechanism of action.