【摘 要】
:
Aim: Cancer immunotherapy has flourished in recent years, however, clinical studies about immunotherapy in combination with chemotherapy, which are still in their infancy, have not achieved a clear an
【机 构】
:
School of Medicine, Ningbo University, Ningbo, Zhejiang 315211
【出 处】
:
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Aim: Cancer immunotherapy has flourished in recent years, however, clinical studies about immunotherapy in combination with chemotherapy, which are still in their infancy, have not achieved a clear and definite consensus on their clinical benefits.Our aim was to investigate whether autologous dendritic cell-cytokine-induced killer cell (DCCIK) immunotherapy could improve the therapeutic benefits of chemotherapy (CT) for advanced non-small cell lung cancer (NSCLC).Methods: A literature search was electronically conducted in PubMed, the Cochrane Central Register of Controlled Trials, CNKI and Wanfang Database for randomized controlled trials (RCTs), and relevant references were also retrieved.
其他文献
Highly pathogenic avian influenza A virus H5N1 continues to spread among poultry and has frequently broken the species barrier to humans, calling for effective vaccines and therapeutics.In this work,
Background : Endogenous antigen encoded by conventional naked DNA was processed by antigen-presenting cells (APCs) and only presented to CD8+ T cell through forming peptide/MHC Ⅰ (major histocompatibi
目的:通过检测miR-155在NK/T细胞淋巴瘤患者外周血及人NK/T细胞淋巴瘤细胞株SNK-6细胞中的表达,探索其与NK/T细胞淋巴瘤临床特征的相关性及其可能的作用机制,以期寻找NK/T细胞淋巴瘤新的肿瘤标记物及预后预测指标.方法:1.研究对象:患者血液标本来自于2013年~2014年3月间,就诊于河北医科大学第四医院血液科的NK/T细胞淋巴瘤患者.所有患者均签署知情同意书.2.人NK/T细胞淋
研究背景:E盒锌指结合蛋白1 (Zinc finger E-box binding homeobox 1,ZEB1)在多种肿瘤中高表达,在某些肿瘤中可以作为预后判断的标志分子.然而,ZEB1在结肠癌中的临床意义尚不明确.目的:在结肠癌组织样本中检测ZEB1的表达水平,分析其与临床病理特征的相关性;在结肠癌HCT116细胞中下调ZEB1的表达,分析其对细胞生物学功能的影响.方法:用免疫组织化学的方法
Macrophages are found in majority of malignant tumors.The object of this study is to evaluate the effect of mmumiR-222 on infiltration of macrophages to breast tumor andstudy the mechanisms ofmmu-miR-
背景:本研究通过构建丙型肝炎病毒(Hepatitis C virus,HCV)基因1b型F基因的真核表达载体,探讨F蛋白对HepG2细胞中Bcl-2和Bax表达的影响.方法:应用聚合酶链式反应(Polymerase Chain reaction,PCR)技术扩增HCV 1b型的F基因,构建pEGFP-C3-F和pEGFP-C3-C真核表达载体,分别将pEGFP-C3-F、pEGFP-C3-C(阳性
研究背景:猪繁殖与呼吸综合征(Porcine reproductive and respiratory syndrome,PRRS)是由猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)引起的猪的一种高度接触性传染性疾病,又称"猪蓝耳病".由于PRRSV是RNA病毒,基因组容易发生变异,变异的病毒株有可能再次
研究背景:2013年3月,在我国上海和安徽等地发现了一种新型禽流感病毒-H7N9的流行,随后在多个省份发现相关病例.鉴于H7N9病毒具有引发大流行的风险,了解机体对这种新病毒的免疫反应特征,对于揭示其致病机制以及指导疫苗的研发等具有重要作用.目的:了解人感染H7N9后机体的免疫反应.方法:对来自21例H7N9感染者的48份血清(包括来自于15例患者的急性期和恢复期配对血清),利用ELISA、抗体亲
目的:研究p53在白藜芦醇(RSV)诱导结肠癌HCT-116细胞自噬和凋亡过程中的作用及机制.方法:RSV处理HCT-116p53+/+和HCT-116p53-/-细胞后,通过MTT法、单丹磺酰戊二胺(MDC)染色、4,6-二脒基-2-苯基吲哚(DAPI)染色、Westem Blotting观察并检测自噬相关蛋白Beclinl、LC3Ⅱ和凋亡相关蛋白Bax、Bcl-2、C-Beclin1等的变化.
The significance of promoter mutation of miRNAs in lung cancer is poorly understood.Recent evidence showed that microRNA-7, a unique family member of miRNAs, was decreased expression and had emerged a