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Rheumatoid arthritis (RA) is a chronic autoimmunity disease which shows synovitis.The activity of SOD in RA patient is reduced,which attenuated the ability to dear free radical.We performed animal experiments to test the effect of the superoxide dismutase (SOD) and the fusion protein (PTD-SOD) consisting of a SOD linked to a protein transduction domain (TAT) in RA treatment.