【摘 要】
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CS1 is a novel 2-phenylnaphthalene having potent cytotoxicity against 9 tested tumor cell lines and potential capability to overcome multidrug resistance.kDNA decatenation, DNA relaxation, cleavage co
【机 构】
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Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences,Shando
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CS1 is a novel 2-phenylnaphthalene having potent cytotoxicity against 9 tested tumor cell lines and potential capability to overcome multidrug resistance.kDNA decatenation, DNA relaxation, cleavage complex assay and Cellular thermal shift assay indicated that CS1 worked as an nonintercalating topoisomerase Ⅱα (Topo Ⅱα)inhibitor by stabilising the Topo Ⅱα cleavage complex.
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