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  5. The expressions of Hesl and Mash1 gene in the process of bone marrow stromal cells differentiating i

The expressions of Hesl and Mash1 gene in the process of bone marrow stromal cells differentiating i

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：Tsianyong
【摘 要】
：
The molecular mechanisms underlying the bone marrow stromal cells (BMSCs) differentiating into neural cells are complex and remain mostly unknown.The basic helix-loop-helix (bHLH) genes,such as Hesl a
【作 者】
：
Hong-En WEI Chun-Fang WANG 
【机 构】
：
Department of Molecular Biology, Medical Experiment Center, Shanxi Medical University, Taiyuan 03000
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
【发表日期】
：
2007年12期
【关键词】
：
bone marrow stromal cells differentiation neural cells Hes1 Mash1 
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　　The molecular mechanisms underlying the bone marrow stromal cells (BMSCs) differentiating into neural cells are complex and remain mostly unknown.The basic helix-loop-helix (bHLH) genes,such as Hesl and Mashl,have been identified to play an important role in neural stem cell differentiation.The aim of our work was to explore the expressions and effects of Hesl and Mashl gene in the process of BMSCs differentiating into neural cells.We isolated BMSCs from adult rats with complete bone marrow blood method.Then BMSCs of passage 3 (abbreviated to P3) were induced into neural cells by B27,bFGF and retinoic acid.Semi-quantitative RT-PCR was used to measure the expressions of Hes1 and Mash1 mRNA in the P3 BMSCs and that after induction for 1 and 3 d.We show that Hesl mRNA was present in undifferentiated BMSCs and had a temporal decrease at 1 d and then a significant increase at 3 d for induced P3 BMSCs.
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