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5. Trisomy chromosome R, a novel chromosomal aneuploidy involved in azole resistance in Candida albican

Trisomy chromosome R, a novel chromosomal aneuploidy involved in azole resistance in Candida albican

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zzqeng

【摘 要】

：

Aim: Genome plasticity is a hallmark in Candida albicans.This study was to examine the potential cause at the genome level of a variant strain CaLY188 in which the complete deletion of SRD1 has been c

【作 者】

：

Lan YAN Xing-xing LI De-dong LI Yong-bing CAO Yan WANG Yuan-ying JIANG 

【机 构】

：

Center for New Drug Research, School of Pharmacy, Second Military Medical University,Shanghai 200433

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

Candida albicans aneuploidy antifungal drug resistance 

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Aim: Genome plasticity is a hallmark in Candida albicans.This study was to examine the potential cause at the genome level of a variant strain CaLY188 in which the complete deletion of SRD1 has been confirmed by PCR while the re-introduction of SRD1 did not restore the decreased azole sensitivity to the wild-type level.

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