To learn the historical adaptations and future responses of wheat production to climatic warming can provide important references to new variety breeding and agronomic innovation.Therefore, an integrated study was conducted in major Chinese winter wheat cropping area based on historical data over 1980-2012 and field warming experiment implemented at four locations for three years.Our results showed that major Chinese winter wheat cropping area had experienced a significantly warming trend, especially daily minimum temperature, while the precipitation didnt change much since 1980.Among the climatic factors, historical increase in daily minimum temperature might have mostly improved winter wheat yield by 140 kg ha-1 ℃-1.No significant impact of precipitation change was found on wheat yield in this country.Field experiment showed that a moderate increase in daily minimum temperature about 1.0 ℃ could significantly enhance wheat yield by 10.1% in the major Chinese cropping area.Warming-led enhancement in grain weight contributed the main part to the increment in wheat yield.The moderate warming greatly reduced the length of wheat pre-flowering phase by 5.4 d averagely, while it significantly prolonged the length of post-flowering phase by 3.8 d.Consequently, no large reduction was found in the length of wheat entire growth period caused by warming.Although there were similar responding trends of wheat growth to climatic warming among the different cropping regions of major Chinese wheat cropping area, warming effect size on wheat phenological phase length decreased along with the background temperature of each region.However, warming-led increments in wheat yield kept more consistent for different regions.