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Objective This study was designed to determine the prevalence and distribution of human papillomavirus(HPV)by a spatial distribution model of the population in various regions of Zhejiang Province,China.Provides epidemiological estimates of high-risk HPV genotype distributions in Zhejiang Province and further demonstrates the thermodynamic chart of the four most common genotypes(HPV16,52,58,and 18).Search for risk factors for HPV infection.Emphasizes the potential importance of the nine valent or nonavalent HPV vaccines.