【摘 要】
：
Chemotherapy of pancreatic cancer is an important non-invasive treatment strategy.However,the traditional method of using anticancer drug Gemcitabine(GEM)is facing the challenges like rapid metabolism
【机 构】
：
MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science a
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Chemotherapy of pancreatic cancer is an important non-invasive treatment strategy.However,the traditional method of using anticancer drug Gemcitabine(GEM)is facing the challenges like rapid metabolism of GEM and poor transport into cells,which eventually results in undesirable therapeutic efficacy(1).The form of prodrug by conjugating GEM to polymers or inorganic nano-carriers is reported to be an effective solution in recent researches(2).Here,a kind of nanocarbon-based material,nanodiamonds(NDs),was selected as the carrier of GEM,considering its outstanding surface properties(3)and non-cytotoxicity(4).
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