Synthesis of fucosylated chondroitin sulfate mimetics via thio-yne click reaction

来源 :第二届糖合成化学青年学术研讨会 | 被引量 : 0次 | 上传用户：zhangqiang

【摘要】

：

　　Fucosylated chondroitin sulfate(fCS) is a unique glycosaminoglycan found in sea cucumber body wall composed of chondroitin sulfate type backbone with sulfat

【作者】

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Fei Fan Ping Zhang Lei Gao Chao Cai Guangli Yu

【机构】

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KeyLaboratoryofMarineDrugs,MinistryofEducation,SchoolofMedicineandPharmacy,OceanUniversityofChina,Qi

【出处】

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第二届糖合成化学青年学术研讨会

【发表日期】

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2017年5期

【关键词】

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Fucosylated chondroitin sulfate Mimetics Fucosylation Thio-yne click

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论文部分内容阅读

　　Fucosylated chondroitin sulfate(fCS) is a unique glycosaminoglycan found in sea cucumber body wall composed of chondroitin sulfate type backbone with sulfated fucose side chains attached.fCS displayed versatile biological activities related to coagulation and thrombosis,tumor growth and inflammation,virus infection,angiogenesis,atherosclerosis,cellular growth,fibrosis,hyperglycemia.

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Synthesis of fucosylated chondroitin sulfate mimetics via thio-yne click reaction

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