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The aim of this study was to clarify the regulatory mechanisms of IL-1β autostimulation in fish immunity, with particular emphasis on the physiological significance of cytokine interactions in inflammatory response.Using grass carp head kidney leukocytes as cell model, we found that exogenous TGF-β1 could impede IL-1β-induced itself gene expression and secretion, presumably through interfering the expression of IL-1β receptor and cytosolic signaling molecules induced by IL-1β.