The traditional concept of biomaterial is now changing from a mere inert supporting matrix towards a biologically active system that can interact with its surrounding environment.Mimicking the structure of naturally occurring proteins by using biopolymers with specific properties is a very promising approach for the development of such new bioactive biomaterials.Progress in recombinant DNA technology allows realization of new artificial protein polymers that can be employed to obtain 3D matrices.A very interesting model for such materials is represented by Human Elastin-Like Polypeptides (HELP),i.e.,repetitive artificial polypeptides based on elastin repeated motifs.