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Aim: To investigate the effects of IMM-YR on insulin resistance and dyslipidemia in dietary-induced obese (DIO) C57BL/6J mice.Methods: Male C57BL/6J mice were fed with high fat diet for 4 months.Obese C57BL/6J mice (DIO-C57) with insulin resistance selected by insulin tolerance test (ITT) were divided into five groups.