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Objective Artesunate(ART)has been used extensively as anti-malarial drugs worldwide.Besids,it has also been reported to have anti-cancer activities.However,few studies have investigated the exact anti-tumor and chemosensitization effects of ART on lung cancer cells.Herein,this study was designed to explore the anti-cancer effects of ART in combination with CIS on lung cancer cells in vitro and vivo,with an emphasis on the molecular mechanism.