Introduction: Tibetan medicine (TM) is a whole systems medical approach that incorporates an extensive materia medica of compounded herbal plants,precious gems and minerals,rejuvenating and detoxifying external therapies,diet and lifestyle guidance,and mental and spiritual practices.Despite growing interest in TM in the West,minimal research,particularly with cancer,has been conducted.The purpose of this article is to provide an overview of TM and to describe a clinical case review study to obtain preliminary evidence of TMs safety and effect on patients treated for cancer or hematologic disorders.Methods: A retrospective case review was conducted at a major TM institute in India.Thorough review of medical records identified those that met the following inclusion criteria: (a) confirmed diagnosis of cancer or hematologic disorder by standard Western biomedical diagnostic tests,(b) either treated exclusively with Tibetan medicine or received inadequate Western treatment (ie,only surgery [without other conventional treatment] followed by Tibetan medicine for stage Ⅲ or Ⅳsolid tumor diagnosis;or insufficient conventional treatment for hematologic disorders [ie,stopping conventional therapies when clinically unstable and/or with active disease]),and (c) were in remission or had stable disease at least 2 years after start of TM.Results: Three cases were identified that met the inclusion criteria,1 solid tumor and 2 hematologic diseases: Case 1-poorly to moderately differentiated adenocarcinoma of the stomach with positive lymph nodes and mucosal infiltration with clear scans and excellent quality of life 29 months after diagnosis and extensive treatment with TM;Case 2-chronic myelogenous leukemia with normalization of hematologic labs within 3 months of starting TM and stable 4 years later;and Case 3-red cell aplasia improved significantly and reversed dependence on blood transfusions with TM,after minimal response to conventional Western approaches.None of the cases experienced demonstrable adverse effects from TM Conclusions: This limited case review found TM to be safe and have positive effects on quality of life and disease regression and remission in patients with cancer and blood disorders.Further exploration and investigation using rigorous methods is warranted.